What is the Karl Fischer Method?
Karl Fischer (KF) titration is an analytical technique designed to accurately determine water content in a wide range of samples, including solids, liquids, and gases.
The method is based on a quantitative chemical reaction between water and the Karl Fischer reagent, which typically consists of iodine, sulfur dioxide, a base, and an alcohol solvent.
A key advantage of the Karl Fischer method is its high selectivity toward water, minimizing interference from other components. This enables precise moisture determination even at trace levels.
Two Common Karl Fischer Methods
Depending on the moisture content of the sample, Karl Fischer titration can be performed using two primary techniques:
Coulometric Titration
This method is suitable for samples with very low moisture content (ppm level). Iodine is generated electrochemically and reacts directly with water in the sample.
Typical applications include:
- Pure solvents
- Gases
- Electronic and semiconductor materials
Volumetric Titration
This method is used for samples with higher moisture content and involves titration with a reagent of known concentration.
Typical applications include:
- Pharmaceuticals
- Food products
- Industrial chemicals
AQUAMICRON – Karl Fischer Reagents by Mitsubishi Chemical Corporation
To ensure the accuracy of Karl Fischer analysis, reagent quality is essential. AQUAMICRON is a comprehensive line of Karl Fischer reagents developed to support both coulometric and volumetric titration systems.
Manufactured under strict ISO 9001 quality control conditions, AQUAMICRON reagents are designed to meet the high standards required in both laboratory and industrial environments.
Key Features of AQUAMICRON
- High accuracy and excellent reproducibility
- Compatibility with a wide range of Karl Fischer titration systems
- Low-toxicity formulations, including pyridine-free options
- Traceability to international standards such as NIST and BIPM
- Suitable for diverse sample types: solvents, oils, pharmaceuticals, gases, and polymers
In addition, AQUAMICRON provides a complete solution for Karl Fischer analysis, including:
- Titrants
- Solvents
- Catholytes
- Certified water standards
This enables users to establish a fully integrated and reliable analytical system.
Applications Across Industries
Due to its flexibility and precision, Karl Fischer titration combined with AQUAMICRON is widely applied in:
- Pharmaceuticals: moisture control in raw materials and finished products
- Chemicals: determination of water as a critical impurity
- Oil and fuels: detection of water affecting performance and durability
- Electronics and materials: trace-level moisture control
In modern production systems, accurate moisture determination plays a key role in ensuring product quality and reducing operational risks.
AQUAMICRON Product Lineup
AQUAMICRON offers a full lineup, eliminating the need to source from multiple suppliers:
Coulometric Reagents
- Anolyte (AX, AS, AKX, etc.)
- Catholyte (CXU)
- Single-solution (FLS)
Volumetric Reagents
- Pyridine-free series (SS-Z series)
- Conventional series (SS series)
Water Standards & System Validation
- Liquid water standards (0.1 – 10 mg/g)
- Solid standards
- Check solutions
Why Choose AQUAMICRON from GKFV?
GKFV is an official distributor of high-quality Japanese chemical products in Vietnam.
By selecting AQUAMICRON through GKFV, customers may benefit from:
- Professional consultation for selecting suitable reagents based on sample types
- Technical support, including method optimization and troubleshooting
- Complete documentation (COA, SDS)
- Stable and reliable supply
